Sang Yup LeeView all speakers
Sang Yup Lee received B.S. in Chem. E. from Seoul National University, and Ph.D. in Chem. E. from Northwestern University. Currently, he is Distinguished Professor, Dean of KAIST Institutes, and Director of Center for Systems and Synthetic Biotechnology, BioProcess Engineering Research Center, and Bioinformatics Research Center at KAIST.
He has published more than 430 journal papers, and numerous patents. He received many awards, including the National Order of Merit, Citation Classic Award, Elmer Gaden Award, Merck Metabolic Engineering Award, ACS Marvin Johnson Award, SIMB Charles Thom Award, and Amgen Biochemical Engineering Award. He is currently Fellow of AAAS, American Academy of Microbiology, Society for Industrial Microbiology and Biotechnology, American Institute of Chemical Engineers, Korean Academy of Science and Technology, and National Academy of Engineering of Korea.
He is also Foreign Associate of National Academy of Engineering USA, Editor-in-Chief of Biotechnology Journal, and editor and board member of many journals.
Bio-based production of chemicals, fuels and materials by microbial fermentation of non-food renewable biomass has become increasingly important due to our increasing concerns on the limited fossil resources and environmental problems. In order to improve the performance of naturally isolated microorganisms, metabolic engineering needs to be performed. Rapid advances in systems biology and synthetic biology are enabling us to approach biological and biotechnological problems at systems level with abilities to finely design and control the metabolic and regulatory circuits. Thus, it is now becoming possible to perform metabolic engineering at the systems level. In this lecture, I will present the general strategies for systems metabolic engineering of microorganisms for the efficient production of chemicals, fuels and materials. The use of synthetic small regulatory RNAs to engineer metabolism at the systems-level will also be described. Several examples on redesigning cellular metabolism for the production of various chemicals and materials will be described. [This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries and by the Intelligent Synthetic Biology Center through the Global Frontier Program from the Ministry of Education, Science and Technology through the National Research Foundation of Korea.]