Richard Murray

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Caltech
Murray, Richard

Richard M. Murray received the B.S. degree in Electrical Engineering from California Institute of Technology in 1985 and the M.S. and Ph.D. degrees in Electrical Engineering and Computer Sciences from the University of California, Berkeley, in 1988 and 1991, respectively. He is currently the Thomas E. and Doris Everhart Professor of Control & Dynamical Systems and Bioengineering at Caltech.

Murray’s research is in the application of feedback and control to networked systems, with applications in biology and autonomy. Current projects include analysis and design biomolecular feedback circuits; specification, design and synthesis of networked control systems; and novel architectures for control using slow computing.

ABSTRACT: Biomolecular Breadboards for Prototyping and Debugging Synthetic Biocircuits

We are developing a set of “biomolecular breadboards” to create a systematic, engineering-oriented approach to synthesizing biomolecular circuits that involves developing, modeling, and debugging a sequence of prototype devices, each at increasing levels of complexity and each allowing the incorporation of increasingly realistic operating environments for either in vitro or in vivo applications.  Our goal is to reduce the iteration time for multiple prototype circuit designs to no more than a day and to design and implement novel, working circuits in cells in as little as a week.  I will focus on our work on using cell-free extracts for this purpose and summarize some of our recent results in modeling, prototyping, debugging and implementing biocircuits using this breadboarding framework.