Patrick Guye

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Guye, Patrick

Patrick Guye is currently a Postdoctoral Research Fellow at the Synthetic Biology Center (Biological Engineering) in the lab of Ron Weiss at MIT. He received his Diploma in Molecular Biology and his Ph.D. In Molecular Infection Biology from the Biozentrum at the University of Basel in Switzerland studying host-pathogen interactions.

Spearheading Synthetic Biology in human stem cells, his current research interest is to understand and harness the engineering principles of our own development. Emergent, multicellular, highly plastic and self-organizing systems keep his clock ticking. With a focus on regenerative medicine, embryonic development and tissue engineering, he is developing methods and tools to generate specialized cell types, tissues and organs from stem cells.

Tue July 9 | 2:00 - 4:00
ABSTRACT: Synthetic Biology in human stem cells: engineering our own building blocks

Induced pluripotent stem (iPS) cells have a tremendous potential for personalized and regenerative medicine, developing novel disease models or investigating the engineering rules of our own development. While the generation of such personalized stem cells became routine in the last years, it remains a challenge to precisely control their differentiation to specific cell types, tissues or organs. We have developed tools to rapidly construct and integrate site-specifically large gene circuits into stem cells where they measure protein and microRNA levels and direct their differentiation. In doing so we demonstrate generation of definitive endoderm, specific neural cell types and mesodermal derivates from human iPS cells. We propose that genetically engineering stem cells by applying principles from Synthetic Biology is a powerful emerging technology with a wide range of uses.