Gyoo Yeol JungView all speakers
Gyoo Yeol Jung is an Associate Professor of Department of Chemical Engineering as well as Head of Interdisciplinary School of Bioscience and Bioengineering, POSTECH of Korea. He received his Ph.D. degree from Seoul National University of Korea and did his postdoc research at MIT with professor Greg Stephanopoulos.
His research is focused on Synthetic Biology and Genetic Analysis System. He published a number of papers in the premier journals including Science and Nature Communications. Dr. Jung is an Associate Editor of Biotechnology and Bioprocess Engineering and editor of Electrophoresis and Journal of Biological Engineering.
Metabolic Engineering aims to purposeful design or redesign biological system for the production of commercially valuable chemicals such as biofuels, platform chemicals and biologically active compounds. To achieve the successful design or redesign of the biological systems, robustness of naturally occurring biological systems has to be relieved so that cells can be easily redesigned. Although extremely huge efforts have been made to find genetic target to improve metabolic function of the microorganisms, there still exists the additional room for the non-rational approach. Currently, typical approach for metabolic engineering uses both rational approach as well as non-rational methods such as combinatorial and evolutionary methods. One of the most critical problems of metabolic engineering is especially robustness of the biological systems. Bacterial cells are generally evolved at the various levels from DNA to protein for maintaining their robustness against the changing circumstances. Therefore, general strategy to modify cellular physiology depending the robustness or flexibility of the biological systems should be required. In this study, we developed intracellular metabolite sensor named “riboselector” to regulate metabolic distribution will be presented. The potentials of the platform technology developed in this study for the application to the production of biofuels and commodity chemicals.